Proteomic evaluation revealed widespread, distinctive and systemic signatures in gender-dependent hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the commonest liver most cancers and is very malignant. Male prevalence and frequent activation of the Ras signaling pathway are distinct traits of HCC. Nonetheless, the underlying mechanisms stay to be elucidated.
- By exploring Hras12V transgenic mice displaying male-biased hepatocarcinogenesis, we carried out a high-throughput comparative proteomic evaluation primarily based on tandem-mass-tag (TMT) labeling mixed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) on the tissue samples obtained from HCC (T) and their paired adjoining precancerous (P) of Hras12V transgenic female and male mice (Ras-Tg) and regular liver (W) of wild-type female and male mice (Non-Tg). The additional validation and investigation had been carried out utilizing quantitative real-time PCR and western blot. Completely, 5193 proteins had been quantified, originating from 5733 recognized proteins.
- Lastly, 1344 differentially expressed proteins (DEPs) (quantified in all examined samples; |ratios| ≥ 1.5, p < 0.05) had been chosen for additional evaluation. Comparability inside W, P, and T of men and women indicated that the variety of DEPs in males was a lot greater than that in females.
- Bioinformatics analyses confirmed the widespread and distinctive cluster-enriched gadgets between sexes, indicating the widespread and gender-disparate pathways in direction of HCC. Expression change sample evaluation revealed HCC optimistic/negative-correlated and ras oncogene optimistic/negative-correlated DEPs and pathways. As well as, it confirmed that the ras oncogene progressively and considerably lowered the responses to intercourse hormones from hepatocytes to hepatoma cells and subsequently shrunk the gender disparity between men and women, which can contribute to the reason for the lack of HCC scientific responses to the therapeutic approaches focusing on intercourse hormone pathways.
- Moreover, gender disparity within the expression ranges of key enzymes concerned in retinol metabolism and terpenoid spine/steroid biosynthesis pathways might contribute to male prevalence in hepatocarcinogenesis. Additional, the biomarkers, SAA2, Orm2, and Serpina1e, could also be intercourse variations. In conclusion, widespread and distinctive DEPs and pathways towards HCC initiated by ras oncogene from sexually dimorphic hepatocytes present beneficial and novel insights into scientific investigation and apply.

ß-OG Lysis Buffer for Proteomics, pH 7.4 |
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22050064-1 | Bio-WORLD | 10 mL | EUR 32.55 |
ß-OG Lysis Buffer for Proteomics, pH 7.4 |
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22050064-2 | Bio-WORLD | 25 mL | EUR 63.96 |
ß-OG Lysis Buffer for Proteomics, pH 7.4 |
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22050064-3 | Bio-WORLD | 50 mL | EUR 105.49 |
AlbuVoid™ LC-MS On-Bead For Serum Proteomics |
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AVB-MS05 | Biotech Support Group | 5 preps | EUR 454.8 |
Description: Albumin Removal Kit |
AlbuVoid™ LC-MS On-Bead For Serum Proteomics |
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AVB-MS10 | Biotech Support Group | 10 preps | EUR 585 |
HemoVoid™ LC-MS On-Bead For Erythrocytes Proteomics |
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HVB-MS05 | Biotech Support Group | 5 preps | EUR 454.8 |
Description: Hemoglobin Removal Kit |
HemoVoid™ LC-MS On-Bead For Erythrocytes Proteomics |
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HVB-MS10 | Biotech Support Group | 10 preps | EUR 585 |
MagSi-proteomics C4 |
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MD01014 | AMSBIO | 2 mL | EUR 391.2 |
MagSi-proteomics C8 |
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MD01015 | AMSBIO | 2 mL | EUR 391.2 |
MagSi-proteomics C4 |
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MD02014 | AMSBIO | 10 mL | EUR 1332 |
MagSi-proteomics C8 |
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MD02015 | AMSBIO | 10 mL | EUR 1332 |
MagSi-proteomics C4 |
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MD03014 | AMSBIO | 100 mL | EUR 7260 |
MagSi-proteomics C8 |
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MD03015 | AMSBIO | 100 mL | EUR 7260 |
MagSi-WCX |
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MD01023 | AMSBIO | 2 mL | EUR 435.6 |
MagSi-WAX |
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MD01025 | AMSBIO | 2 mL | EUR 435.6 |
MagSi-WCX |
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MD02023 | AMSBIO | 10 mL | EUR 1488 |
MagSi-WAX |
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MD02025 | AMSBIO | 10 mL | EUR 1488 |
MagSi-WCX |
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MD03023 | AMSBIO | 100 mL | EUR 7260 |
MagSi-WAX |
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MD03025 | AMSBIO | 100 mL | EUR 7260 |
MagSi-cfDNA |
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MDKT00220096 | AMSBIO | 96 preps | EUR 1056 |
MagSi-S 1.0 |
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MD01003 | AMSBIO | 2 mL | EUR 58.8 |
MagSi-S 1.0 |
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MD03003 | AMSBIO | 10 mL | EUR 163.2 |
MagSi-S 1.0 |
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MD04003 | AMSBIO | 100 mL | EUR 1296 |
MagSi-S 600 |
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MD16003 | AMSBIO | 2 mL | EUR 61.2 |
MagSi-S 600 |
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MD18003 | AMSBIO | 10 mL | EUR 170.4 |
MagSi-S 600 |
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MD19003 | AMSBIO | 100 mL | EUR 1500 |
MagSi-S 3.0 |
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MD41003 | AMSBIO | 2 mL | EUR 58.8 |
MagSi-S 3.0 |
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MD43003 | AMSBIO | 10 mL | EUR 163.2 |
MagSi-S 3.0 |
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MD44003 | AMSBIO | 100 mL | EUR 1296 |
MagSi-STA 1.0 |
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MD01001 | AMSBIO | 2 mL | EUR 426 |
MagSi-DNA 600 |
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MD01016 | AMSBIO | 2 mL | EUR 87.6 |
MagSi-DNA 3.0 |
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MD01022 | AMSBIO | 2 mL | EUR 87.6 |
MagSi-DNA mf |
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MD0200010002 | AMSBIO | 2 mL | EUR 114 |
MagSi-DNA mf |
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MD0200010010 | AMSBIO | 10 mL | EUR 441.6 |
MagSi-DNA mf |
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MD0200010100 | AMSBIO | 100 mL | EUR 3618 |
MagSi-DNA 600 |
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MD02016 | AMSBIO | 10 mL | EUR 339.6 |
MagSi-STA 1.0 |
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MD03001 | AMSBIO | 10 mL | EUR 1434 |
MagSi-DNA 600 |
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MD03016 | AMSBIO | 100 mL | EUR 2796 |
MagSi-DNA 3.0 |
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MD03022 | AMSBIO | 10 mL | EUR 339.6 |
MagSi-STA 1.0 |
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MD04001 | AMSBIO | 100 mL | EUR 7158 |
MagSi-DNA 3.0 |
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MD04022 | AMSBIO | 100 mL | EUR 2796 |
MagSi-STA 600 |
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MD16001 | AMSBIO | 2 mL | EUR 470.4 |
MagSi-STA 600 |
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MD18001 | AMSBIO | 10 mL | EUR 1572 |
MagSi-STA 600 |
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MD19001 | AMSBIO | 100 mL | EUR 9060 |
MagSi-DNA FFPE |
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MDKT00240096 | Magtivio | 96 preps | EUR 586.88 |
MagSi-DNA FFPE |
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MDKT00240960 | Magtivio | 10 x 96 preps | EUR 4692.8 |
MagSi-DNA Stool |
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MDKT00230096 | Magtivio | 96 preps | EUR 412.16 |
MagSi-DNA Stool |
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MDKT00230960 | Magtivio | 10 x 96 preps | EUR 3498.88 |
MagSi-DT Removal* |
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MDKT00040008 | AMSBIO | 8 mL | EUR 181.2 |
MagSi-DT Removal* |
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MDKT00040050 | AMSBIO | 50 mL | EUR 1092 |
MagSi-DT Removal* |
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MDKT00040500 | AMSBIO | 500 mL | EUR 6426 |
MagSi-DNA Animal |
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MDKT00150096 | AMSBIO | 96 preps | EUR 259.2 |
MagSi-DNA Animal |
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MDKT00150960 | AMSBIO | 10 x 96 preps | EUR 2076 |
MagSi-protein A 1.0 |
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MD01011 | AMSBIO | 1 mL | EUR 152.4 |
MagSi-protein G 1.0 |
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MD01012 | AMSBIO | 1 mL | EUR 152.4 |
MagSi-protein A 1.0 |
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MD02011 | AMSBIO | 5 mL | EUR 607.2 |
MagSi-protein G 1.0 |
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MD02012 | AMSBIO | 5 mL | EUR 607.2 |
MagSi-protein A 600 |
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MD10011 | AMSBIO | 1 mL | EUR 181.2 |
MagSi-protein G 600 |
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MD10012 | AMSBIO | 1 mL | EUR 181.2 |
MagSi-protein A 600 |
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MD11011 | AMSBIO | 5 mL | EUR 722.4 |
MagSi-protein G 600 |
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MD11012 | AMSBIO | 5 mL | EUR 722.4 |
MagSi-protein A 3.0 |
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MD41011 | AMSBIO | 1 mL | EUR 152.4 |
MagSi-protein G 3.0 |
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MD41012 | AMSBIO | 1 mL | EUR 152.4 |
MagSi-protein A 3.0 |
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MD42011 | AMSBIO | 5 mL | EUR 607.2 |
MagSi-protein G 3.0 |
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MD42012 | AMSBIO | 5 mL | EUR 607.2 |
MagSi-DX Pathogen |
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MDDX0001005K | AMSBIO | 5K preps | EUR 11880 |
MagSi-DX Pathogen |
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MDDX00010096 | AMSBIO | 96 preps | EUR 300 |
MagSi-DX Pathogen |
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MDDX0001025K | AMSBIO | 25K preps | EUR 58800 |
MagSi-DX Pathogen |
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MDDX00010960 | AMSBIO | 10x96 preps | EUR 2398.8 |
MagSi-DNA allround |
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MD01018 | AMSBIO | 2 mL | EUR 87.6 |
MagSi-DNA allround |
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MD02018 | AMSBIO | 10 mL | EUR 339.6 |
MagSi-DNA allround |
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MD03018 | AMSBIO | 100 mL | EUR 2796 |
MagSi-NGSPREP Plus* |
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MDKT00010005 | AMSBIO | 5 mL | EUR 76.8 |
MagSi-NGSPREP Plus* |
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MDKT00010075 | AMSBIO | 75 mL | EUR 714 |
MagSi-NGSPREP Plus* |
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MDKT00010500 | AMSBIO | 500 mL | EUR 3564 |
MagSi-NA Pathogens |
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MDKT0021005K | AMSBIO | 5K preps | EUR 11880 |
MagSi-NA Pathogens |
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MDKT00210096 | AMSBIO | 96 preps | EUR 300 |
MagSi-NA Pathogens |
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MDKT0021025K | AMSBIO | 25K preps | EUR 58800 |
MagSi-NA Pathogens |
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MDKT00210960 | AMSBIO | 10x96 preps | EUR 2398.8 |
MagSi-S SH 1.0 |
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MD03006 | AMSBIO | 10 mL | EUR 483.6 |
MagSi-S SH 1.0 |
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MD04006 | AMSBIO | 100 mL | EUR 1548 |
MagSi-S SH 600 |
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MD18006 | AMSBIO | 10 mL | EUR 538.8 |
MagSi-S SH 600 |
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MD19006 | AMSBIO | 100 mL | EUR 1854 |
MagSi-S SH 3.0 |
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MD43006 | AMSBIO | 10 mL | EUR 483.6 |
MagSi-S SH 3.0 |
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MD44006 | AMSBIO | 100 mL | EUR 1548 |
MagSi-S NH2 1.0 |
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MD01005 | AMSBIO | 2 mL | EUR 73.2 |
MagSi-S NH2 1.0 |
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MD03005 | AMSBIO | 10 mL | EUR 204 |
Identification and Validation of Stage-Related PBMC Biomarkers in Breast Most cancers Utilizing MS-Primarily based Proteomics
Background: It’s well-described that the transcriptome of peripheral blood mononuclear cells (PBMCs) might be altered within the context of many malignancies to permit them keep away from the efficient immune response, which ends up in most cancers invasiveness. Right here, we used an MS-based technique to find biomarkers within the PBMCs of breast most cancers (BC) sufferers and validated them at completely different phases of BC.
Strategies: PBMCs had been remoted from the breast most cancers sufferers and had been cultured alone or co-cultured with breast most cancers cell traces. The function of PBMC within the invasion property of breast most cancers cells was explored. NF-kB exercise was additionally measured within the co-cultured breast most cancers cells. Identification of protein profiles within the secretome and proteome of the co-cultured PBMCs was carried out utilizing SWATH mass spectrometry. Pathway enrichment and gene ontology analyses had been carried out to search for the molecular pathways correlated with the protein expression profile of PBMCs within the breast most cancers sufferers. Quantitative real-time polymerase chain response (qPCR) was carried out to validate the candidate genes within the PBMC fraction of the breast most cancers sufferers on the major and metastatic phases. In silico survival evaluation was carried out to evaluate the potential scientific biomarkers in these PBMC subtypes.
Outcomes: PBMCs might considerably enhance the invasion property of the BC cells concomitant with a lower in E-cadherin and a rise in each Vimentin and N-cadherin expression. The NF-kB exercise within the BC cells considerably elevated following co-culturing implying the function of PBMCs in EMT induction. Enrichment evaluation confirmed that the differentially expressed proteins in PBMCs are primarily related to IL-17, PI3K-Akt, and HIF-1 signaling pathway, through which a set of seven proteins together with TMSB4X, HSPA4, S100A9, SRSF6, THBS1, CUL4A, and CANX had been incessantly expressed. Lastly, in silico evaluation confirmed {that a} gene set consisting of S100A9, SRSF6, THBS1, CUL4A, and CANX had been discovered to offer an perception for the identification of metastasis in breast most cancers sufferers.
Conclusion: In conclusion, our research revealed that the protein expression profile in PBMCs is a mirrored image of the proteins expressed within the BC tissue itself; nonetheless, the abundance degree is completely different because of the stage of most cancers.
Protein L Magnetic beads |
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EA-IP-017M | Elabscience Biotech | 1mL | EUR 105 |
Description: Primary Antibodies |
Magnetic Beads (RNA) |
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AG0104 | AcceGen | 5 ml, 60 ml | Ask for price |
Description: The Magnetic Beads (RNA)</strong> are automated for highly efficient RNA purification by specific adsorption. |
96 Magnetic Stand (For Magnetic Beads DNA/RNA Extraction/Magnetic Beads DNA/RNA Extraction) |
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MNS096-W | Geneaid Biotech | each | EUR 70 |
Protein A/G Magnetic Beads |
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6527-1 | Biovision | each | EUR 352.8 |
Protein A/G Magnetic Beads |
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HY-K0202 | MedChemExpress | 1 mL | EUR 157.2 |
Protein A/G Magnetic Beads |
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EA-IP-007M | Elabscience Biotech | 1mL | EUR 80 |
Description: Primary Antibodies |
Streptavidin Magnetic Beads |
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CSB001 | Signosis | 15 μl | EUR 61 |
Streptavidin Magnetic Beads |
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HY-K0208 | MedChemExpress | 5 mL | EUR 645.6 |
Streptavidin Magnetic beads |
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EA-IP-011M | Elabscience Biotech | 1mL | EUR 241 |
Description: Primary Antibodies |
Anti-HA magnetic beads |
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B26201 | Bimake | 1 mL | EUR 579.6 |
Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification. |
Anti-HA magnetic beads |
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B26202 | Bimake | 5 mL | EUR 1742.4 |
Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification. |
Anti-HA Magnetic Beads |
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HY-K0201 | MedChemExpress | 1 mL | EUR 334.8 |
SILICA MAGNETIC BEADS 1L |
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L5011001 | Biochain | 1 liter | EUR 5336.1 |
Protein A/G/L Magnetic Beads |
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6547-1 | Biovision | each | EUR 405.6 |
Anti-Myc magnetic beads |
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B26301 | Bimake | 1 mL | EUR 579.6 |
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification. |
Anti-Myc magnetic beads |
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B26302 | Bimake | 5 mL | EUR 1742.4 |
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification. |
Anti-Flag magnetic beads |
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B26101 | Bimake | 1 mL | EUR 579.6 |
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification. |
Anti-Flag magnetic beads |
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B26102 | Bimake | 5 mL | EUR 1742.4 |
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification. |
DNA Cleanup Magnetic Beads |
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AG0311L | AcceGen | 5 ml, 60 ml | Ask for price |
Description: DNA Cleanup Magnetic Beads are superparamagnetic, non-aggregating iron oxide particles (or ‘microspheres’) which can bind DNA ant high capcity. The highly efficient DNA purification magnetic beads are based clean-up system for the purification of DNA for NGS workflows. Superior yield, purity, and quality over the leading competitors, all at a better value, because we design and manufacture them in-house. DNA Cleanup Magnetic Beads enables faster binding kinetics, with high sensitivity & selectivity, in both manual and automated biomedical and research applications. The purified DNA is of high yield and integrity and is free of inhibitors, ready for use in a number of downstream applications including PCR, qPCR, mutation screening, microarray analysis, sequencing, single nucleotide polymorphism (SNP) and short-tandem repeat (STR) genotyping. |
Anti-Flag Magnetic Beads |
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HY-K0207 | MedChemExpress | 1 mL | EUR 570 |
SILICA MAGNETIC BEADS 10ML |
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L5011010 | Biochain | 10 ml | EUR 53.55 |
BlackPearl® (Magnetic Beads) |
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20161006-1 | Bio-WORLD | - | Ask for price |
BlackPearl® (Magnetic Beads) |
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20161006-2 | Bio-WORLD | - | Ask for price |
BlackPearl® (Magnetic Beads) |
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20161006-3 | Bio-WORLD | - | Ask for price |
Magnetic Beads (DNA) 30 mL |
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P920-30 | 101Bio | 30 mL | EUR 399 |
Magnetic Beads (DNA) 450 mL |
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P920-450 | 101Bio | 450 mL | EUR 3999 |
Magnetic Beads (DNA) 5 mL |
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P920-5 | 101Bio | 5 mL | EUR 99 |
Magnetic Beads (DNA) 60 mL |
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P920-60 | 101Bio | 60 mL | EUR 699 |
Concanavalin A Magnetic Beads |
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K1308-1 | ApexBio | 1ml | EUR 44.8 |
Description: Protein & Immunology|Protein Purification and isolation |
Concanavalin A Magnetic Beads |
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K1308-5 | ApexBio | 5x1ml | EUR 196.8 |
Description: Protein & Immunology|Protein Purification and isolation |
Concanavalin A Magnetic beads |
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EA-IP-014M | Elabscience Biotech | 1mL | EUR 159 |
Description: Primary Antibodies |
Magnetic Beads™ Streptavidin |
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SMB-B01 | ACROBIOSYSTEMS | 5mg | EUR 250.7 |
Description: The Streptavidin-Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of streptavidin (SA). The beads can be used to capture the biotinylated proteins or other molecules, because Streptavidin (SA) has an extraordinarily high affinity for biotin with a dissociation constant (Kd) on the order of 10−14 mol/L, the Biotinylated molecules can bind to the SA irreversibly.Streptavidin is a tetrameric protein purified from the bacterium Streptomyces avidin, and exhibits high binding affinity for biotin. Able to bind one molecule of biotin with each subunit. Streptavidin (PI=6.0-7.5) has lower level of non-specific binding to various biological components at physiological pH than avidin (PI=7.4), resulting from its isoelectric point (PI).The Streptavidin-Magnetic Beads is easy to capture the biotinylated proteins or other molecules in Chemiluminescence procedures, and the bounded protein have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results. |
IP/CoIP Kit (Magnetic Beads) |
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EA-IP-K007M | Elabscience Biotech | 50T | EUR 700 |
Description: Antibody Application Reagents |
Protein A/G Magnetic Beads for IP |
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B23201 | Bimake | 1 ml | EUR 158.4 |
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens. |
Protein A/G Magnetic Beads for IP |
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B23202 | Bimake | 5 ml | EUR 558 |
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens. |
Protein A BlackPearl® (Magnetic Beads) |
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20161000-1 | Bio-WORLD | - | Ask for price |
Protein A BlackPearl® (Magnetic Beads) |
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20161000-2 | Bio-WORLD | - | Ask for price |
Protein A BlackPearl® (Magnetic Beads) |
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20161000-3 | Bio-WORLD | - | Ask for price |
Protein G BlackPearl® (Magnetic Beads) |
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20161003-1 | Bio-WORLD | - | Ask for price |
Protein G BlackPearl® (Magnetic Beads) |
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20161003-2 | Bio-WORLD | - | Ask for price |
Anti-c-Myc Magnetic Beads |
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HY-K0206 | MedChemExpress | 5 mL | EUR 1368 |
Magnetic Beads PCR Cleanup Kit |
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MC004 | Geneaid Biotech | each | EUR 3 |
Magnetic Beads PCR Cleanup Kit |
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MC048 | Geneaid Biotech | each | EUR 25 |
Magnetic Beads PCR Cleanup Kit |
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MC096 | Geneaid Biotech | each | EUR 45 |
Anti-tGFP magnetic beads, 1ml |
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TA150039 | Origene Technologies GmbH | 1 ml | Ask for price |
Anti-tGFP magnetic beads, 5ml |
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TA150040 | Origene Technologies GmbH | 5 ml | Ask for price |
9E10, Anti-Myc Magnetic beads |
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TA150044 | Origene Technologies GmbH | 1 ml | Ask for price |
9E10, Anti-Myc Magnetic beads |
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TA150045 | Origene Technologies GmbH | 5 ml | Ask for price |
Anti-HA (Nanobody) Magnetic Beads |
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AE109 | Abclonal | 500μL | EUR 382.59 |
Anti-GFP (Nanobody) Magnetic Beads |
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AE079 | Abclonal | 500μL | EUR 382.59 |
Anti-Myc (Nanobody) Magnetic Beads |
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AE107 | Abclonal | 1000μL | EUR 226.72 |
Human FAP-coupled Magnetic Beads |
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MBS-K077 | ACROBIOSYSTEMS | 10mg | EUR 882.9 |
Description: The biotinylated FAP protein was conjugated to streptavidin magnetic beads. This pre-coupled magnetic bead product can capture the anti-FAP antibody from various assay systems. The beads are in uniform size, narrow size distribution with large surface area and unique surface coating, which can help you get the best performance and highly reproducible results. This FAP coupled magnetic beads will bring great convenience with minimum non-specific binding and developed protocols. This ready-to-use product could greatly save your time and hassle. |
Anti-GFP (Nanobody) Magnetic Beads |
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E45R13193N | EnoGene | 500 ul | EUR 570.75 |
Anti-GFP (Nanobody) Magnetic Beads |
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MBS9143967-INQUIRE | MyBiosource | INQUIRE | Ask for price |
DDDDK-Tag Antibody (Magnetic Beads) |
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abx005594-100l | Abbexa | 100 µl | EUR 250 |
Human CD33-coupled Magnetic Beads |
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MBC-K008 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human CD33 protein is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259(Accession # P20138-1(R69G)). |
Human CD38-coupled Magnetic Beads |
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MBC-K010 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human CD38 protein is expressed from human 293 cells (HEK293). It contains AA Val 43 - Ile 300(Accession # P28907-1). |
Human EGFR-coupled Magnetic Beads |
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MBE-K012 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human EGFR protein is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 645(Accession # P00533-1). |
Human PSMA-coupled Magnetic Beads |
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MBP-K007 | ACROBIOSYSTEMS | 2mg | EUR 3411.7 |
Description: Human PSMA protein is expressed from human 293 cells (HEK293). It contains AA Lys 44 - Ala 750(Accession # Q04609-1). |
Human ROR1-coupled Magnetic Beads |
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MBR-K009 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human ROR1 protein is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403(Accession # Q01973-1). |
Human BCMA-coupled Magnetic Beads |
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MBS-K004 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human BCMA protein is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54(Accession # Q02223-1). |
Human CD19-coupled Magnetic Beads |
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MBS-K005 | ACROBIOSYSTEMS | 2mg | EUR 4392.7 |
Description: Human CD19 protein is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291(Accession # P15391-1). |
Human CD19-coupled Magnetic Beads |
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MBS-K005-10mg | ACROBIOSYSTEMS | 10mg | EUR 4392.7 |
Description: Human CD19 protein is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291(Accession # P15391-1). |
Human CD19-coupled Magnetic Beads |
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MBS-K005-2mg | ACROBIOSYSTEMS | 2mg | EUR 1427.9 |
Description: Human CD19 protein is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291(Accession # P15391-1). |
Human HER2-coupled Magnetic Beads |
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MBS-K006 | ACROBIOSYSTEMS | 500ug | EUR 2888.5 |
Description: Human HER2 protein is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652(Accession # P04626-1). |
Human ACE2-coupled Magnetic Beads |
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MBS-K013 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human ACE2 protein is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740(Accession # Q9BYF1-1). |
Human CD73-coupled Magnetic Beads |
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MBS-K022 | ACROBIOSYSTEMS | 2mg | EUR 3411.7 |
Description: Human CD73 Protein is expressed from human 293 cells (HEK293). It contains AA Trp 27 - Ser 549(Accession # P21589-1). |
Human CD47-coupled Magnetic Beads |
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MBS-K023 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human CD47 Protein is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139(Accession # Q08722). |
Human CD3E-coupled Magnetic Beads |
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MBS-K026 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human CD3E Protein is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126(Accession # P07766-1). |
Human CD22-coupled Magnetic Beads |
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MBS-K052 | ACROBIOSYSTEMS | 2mg | EUR 4392.7 |
Description: Human CD22 Protein is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 687(Accession # P20273-1). |
Human DLL3-coupled Magnetic Beads |
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MBS-K053 | ACROBIOSYSTEMS | 2mg | EUR 2707.1 |
Description: Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues. |
Human uPAR-coupled Magnetic Beads |
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MBS-K076 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Tumors are the result of uncontrolled proliferation of cells in different organs. Tumor development is a multistage process, that includes the generation of primary tumors, separation of tumors from primary sites, degradation of extracellular matrix (ECM), and distant metastasis of tumors. A variety of genes play important roles in the development of tumors, including the cell surface receptor urokinase-type plasminogen activator receptor (uPAR). uPAR is highly expressed in a variety of tumor cells, and a variety of signals regulated by uPAR play significant roles in tumor cell proliferation and metastasis, tumor-related glycolysis, the tumor microenvironment and angiogenesis. Studies have found that some specific drugs and antibodies have unique inhibitory effects on uPAR. |
Magnetic Beads for DNA Purification |
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M1502-5 | Biovision | 5 ml | EUR 332.4 |
Amylose BlackPearl® (Magnetic Beads) |
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20161009-1 | Bio-WORLD | - | Ask for price |
Amylose BlackPearl® (Magnetic Beads) |
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20161009-2 | Bio-WORLD | - | Ask for price |
Human PCSK9-coupled Magnetic Beads |
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MBS-K054 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). |
Human ASGR1-coupled Magnetic Beads |
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MBS-K055 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver. |
Human ANGPT2-coupled Magnetic Beads |
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MBS-K035 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human ANGPT2 Protein is expressed from human 293 cells (HEK293). It contains AA Lys 275 - Phe 496(Accession # O15123-1). |
Human VEGF165-coupled Magnetic Beads |
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MBS-K036 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human VEGF165 Protein is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 191(Accession # P15692-4). |
Ni-NTA Magnetic Agarose Beads |
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20-512M1 | Genesee Scientific | 2ml/Unit | EUR 116.39 |
Description: Suspension, 5% Magnetic Resin |
Ni-NTA Magnetic Agarose Beads |
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20-512M2 | Genesee Scientific | 5ml/Unit | EUR 263.6 |
Description: Suspension, 5% Magnetic Resin |
Ni-NTA Magnetic Agarose Beads |
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20-512M3 | Genesee Scientific | 10ml/Unit | EUR 477.13 |
Description: Suspension, 5% Magnetic Resin |
Human EGFRvIII-coupled Magnetic Beads |
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MBS-K020 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human EGFRvIII Protein is expressed from human 293 cells (HEK293). It contains AA Leu 25- Ser 378(Accession # NP_001333870.1). |
Human HGF R-coupled Magnetic Beads |
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MBS-K021 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human HGF R Protein is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Thr 932(Accession # P08581). |
Streptavidin BlackPearl® (Magnetic Beads) |
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20161004-1 | Bio-WORLD | - | EUR 135.06 |
Streptavidin BlackPearl® (Magnetic Beads) |
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20161004-2 | Bio-WORLD | - | EUR 428.2 |
Human Mesothelin-coupled Magnetic Beads |
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MBS-K024 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human Mesothelin Protein is expressed from human 293 cells (HEK293). It contains AA Glu 296 - Gly 580(Accession # Q13421-3(R309P)). |
Magnetic Beads for DNA size selection |
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AG0103 | AcceGen | 5 ml, 60 ml | Ask for price |
Description: The Magnetic Beads are ideal for DNA purification, concentration and size selection, along with next-generation sequencing library preparation kits. |
Human CTLA-4 coupled Magnetic Beads |
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MBS-K042 | ACROBIOSYSTEMS | 2mg | EUR 2757.7 |
Description: Human CTLA-4 Protein is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162(Accession # Q6GR94-1). |
Magnetic Beads DNA Extraction Kit (Food) |
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MF004 | Geneaid Biotech | each | EUR 3 |
Magnetic Beads DNA Extraction Kit (Food) |
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MF048 | Geneaid Biotech | each | EUR 55 |
Magnetic Beads DNA Extraction Kit (Food) |
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MF096 | Geneaid Biotech | each | EUR 99 |
VAHTS Concanavalin A-coated Magnetic Beads Pro |
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N515-01-250ul | Vazyme | 250 μl | EUR 38.7 |
VAHTS Concanavalin A-coated Magnetic Beads Pro |
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N515-02-1ml | Vazyme | 1 ml | EUR 129.71 |
VAHTS Concanavalin A-coated Magnetic Beads Pro |
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N515-03-5ml | Vazyme | 5 ml | EUR 610.95 |